| Title | Year | Status | Character |
|---|
| Bodied | 2017 | post-production | |
| The Invisible Mother | 2017/II | post-production | Glorianna |
| The Invisible Mother | 2017/I | filming | Glorianna |
| Her Side of the Bed | 2016 | post-production | |
| WTF: World Thumbwrestling Federation | 2016 | completed | Geri McFlem |
| Lotto | | filming | Randi Body |
| Turning Tables | | announced | Tasha |
| Adults Only | 2017 | TV Series announced | Linda Law |
| This is Meg | 2017 | | Sasha |
| Open Marriage | 2017 | TV Movie | Vulnavia |
| Let It Die | 2016 | Video Game | Player Character (voice) |
| Fainaru fantajî XV | 2016 | Video Game | Additional Voices (English version, voice) |
| Z Nation | 2016 | TV Series | Linda |
| Life in Pieces | 2016 | TV Series | Leigh |
| Call of Duty: Infinite Warfare | 2016 | Video Game voice, as Debra R Wilson | |
| Then What Happened? | 2016 | TV Series | Estelle Jenkins |
| Gears of War 4 | 2016 | Video Game | Ashpo Point Gear (voice) |
| Mafia III | 2016 | Video Game | Additional Voices (voice) |
| World of Warcraft: Legion | 2016 | Video Game voice | |
| Untitled MadTV Revival | 2016 | TV Series | Various |
| All Hail King Julien | 2014-2016 | TV Series | Masikura / Tammy / Mary Ann / ... |
| Mirror's Edge: Catalyst | 2016 | Video Game | Rebecca Thane (voice) |
| American Dad! | 2005-2016 | TV Series | Mom at basketball game / Whitney Houston |
| Dead 7 | 2016 | | Apocolypta |
| Angel from Hell | 2016 | TV Series | Pam |
| Far Cry Primal | 2016 | Video Game | Batari (voice) |
| My Sister Is So Gay | 2016 | TV Series | Becca |
| Caged No More | 2016 | | Leona |
| Pig Goat Banana Cricket | 2016 | TV Series | Nasty Cat / Mrs. Manelli / Lady Fart |
| Living Room Coffin | 2016 | | Val Pocalypse |
| The Summerland Project | 2016 | | Adah Allen |
| Hotel Transylvania 2 | 2015 | | Additional Voices (voice) |
| RelationFixTM | 2015 | TV Series | Dana |
| Midlife | 2015 | | Diane Freeland |
| Mothers of the Bride | 2015 | | Freesia the Producer |
| Black Dynamite | 2012-2015 | TV Series | Amazon Moon Bitch Leader |
| The Hobbit: The Battle of the Five Armies | 2014 | | Creature Voices (voice) |
| World of Warcraft: Warlords of Draenor | 2014 | Video Game | Monster Vocal Effects (voice) |
| Call of Duty: Advanced Warfare | 2014 | Video Game | Additional Voices (voice) |
| Untold | 2014/II | | Merrel |
| The 10 Year Plan | 2014 | | Minister |
| Fatal Acquittal | 2014 | TV Movie | Detective Bell |
| Naked Angel | 2014 | | Mama Tony |
| Wildstar | 2014 | Video Game | Dreadphage Ohmna / Selene / Granok Female (voice) |
| Knock 'em Dead | 2014 | | Darien Grey |
| Super-Pets | 2013-2014 | TV Series | Jumpa / Aqua Cow / Streaky |
| Jungle Shuffle | 2014 | | Kam (voice, as Debra Willson) |
| Elder Scrolls Online | 2014 | Video Game | Additional Voices (voice) |
| Regular Show in Space | 2014 | TV Series | Council Woman / Thunder Girl 1 / Blonde Girl |
| Doom Patrol | 2013 | TV Series | Madame Rouge |
| Mad | 2013 | TV Series | Major Gwen Anderson / Cavewoman / Mom |
| Grand Theft Auto V | 2013 | Video Game | The Local Population (voice) |
| Lips | 2012-2013 | TV Mini-Series | X-girlfriend |
| Save Me | 2013 | TV Series | Stephanie |
| The Cleveland Show | 2013 | TV Series | |
| The First Family | 2013 | TV Series | Helen |
| 2 Broke Girls | 2013 | TV Series | Delores |
| Bed-Stuy Lullaby | 2012 | Short | Sha'rell |
| G-Block: Doing Time Was Never More Fun | 2012 | Short | |
| Back Then | 2012 | | Georiga Miller |
| Infamous 2: Festival of Blood | 2011 | Video Game | Storyteller / Femle Pedestrians (voice) |
| Division III: Football's Finest | 2011 | | Mandy |
| Family Guy | 2000-2011 | TV Series | Black Woman Whitney Houston Star Jones ... |
| Infamous 2 | 2011 | Video Game | Female Pedestrians / The Storyteller - Festival of Blood DLC (voice) |
| Oprah's Last Show | 2011 | Video short | Oprah Winfrey |
| Hoodwinked Too! Hood vs. Evil | 2011 | | Iana (voice, as Debra Wilson Skelton) |
| The Fresh Beat Band | 2011 | TV Series | TV Announcer |
| Fallout: New Vegas | 2010 | Video Game | Kate / Sweeite / Yvette / ... (voice) |
| Friends & Lovers | 2010 | TV Series | Paula |
| StarCraft II: Wings of Liberty | 2010 | Video Game | Additional Voices (voice) |
| Perfect Combination | 2010 | | Mrs. Lewis |
| Dead to Rights: Retribution | 2010 | Video Game | Security Guard (voice) |
| Friends of Dorothy | 2009 | Short | Hillary |
| Guess Again | 2009 | TV Series short | Lorraine |
| Avatar | 2009 | | Troupe (as Debra Skelton) |
| The Princess and the Frog | 2009 | Video Game | Eudora (voice, as Debra Skelton) |
| Halo 3: ODST | 2009 | Video Game | Marine #4 (voice, as Debra Wilson Skelton) |
| The Haunted World of El Superbeasto | 2009 | Video | Cigarette Girl Bride Fronkenstein Female Patron ... (voice) |
| MADtv | 1995-2009 | TV Series | Various / Lowered Expectations Guide / Rosa Marticorena / ... |
| Psyche on Melrose | 2009 | Short | Hostess |
| Scrubs | 2009 | TV Series | Whitney |
| 90210 | 2009 | TV Series | Teacher |
| Fracture | 2008 | Video Game voice | |
| Terminator: The Sarah Connor Chronicles | 2008 | TV Series | Lilian |
| Friends & Lovers: The Ski Trip 2 | 2008 | | Paula |
| Metal Gear Solid 4: Guns of the Patriots | 2008 | Video Game | Crying Wolf (English version, voice, as Debra Wilson Skelton) |
| No News Is Good News! | 2008 | Video short | Host |
| Reno 911! | 2008 | TV Series | Dominatrix |
| Speed Racer | 2008 | Video Game | Booster Mbube (voice, as Debra Wilson Skelton) |
| The Boondocks | 2008 | TV Series | Debra Leevil |
| Cuttin Da Mustard | 2008 | | Actress |
| Higglytown Heroes | 2007 | TV Series | Marine Biologist Hero |
| The Chosen One | 2007 | | Akia May (voice) |
| CSI: Crime Scene Investigation | 2004-2007 | TV Series | Divine |
| Cordially Invited | 2007 | | Vivian Dunn |
| Halo 3 | 2007 | Video Game | Marines (voice, as Debra Wilson Skelton) |
| Super Sweet 16: The Movie | 2007 | TV Movie | Eden Day |
| Lord Help Us | 2007 | Video | Shariffer Simms |
| If I Had Known I Was a Genius | 2007 | | Teresa Reed |
| City Girls | 2007 | TV Movie | Jen Chase |
| Rockin' Meera | 2006 | | Rudy |
| Shut Up and Shoot! | 2006 | | Nikki Ryder |
| Mandingo in a Box | 2006 | Short | Host |
| X-Men: The Official Game | 2006 | Video Game | Storm (voice) |
| Over the Hedge | 2006 | | Debbie (voice) |
| Scary Movie 4 | 2006 | | Oprah |
| The Adventures of Brer Rabbit | 2006 | Video | Sister Buzzard (voice) |
| Ice Age 2: The Meltdown | 2006 | Video Game | Ellie (voice) |
| Danny Roane: First Time Director | 2006 | | Rehab Nurse |
| In Justice | 2006 | TV Series | Detective Powell |
| Whitepaddy | 2006 | | Aunt Tiny |
| Bringing Up BayBay | 2005 | Short | Pam / BayBay Girl |
| Studio House | 2005 | TV Movie | Vicky |
| Second Time Around | 2005 | TV Series | Deonne |
| Knight to F4 | 2005 | | Cheryl Johnson |
| Nine Lives | 2004 | | Lisa |
| Hot Shots Golf Fore! | 2004 | Video Game | Various Voices (voice) |
| That's So Raven | 2004 | TV Series | Maisha |
| I'm with Her | 2004 | TV Series | Brenda |
| Cock-a-Doodle-Duel | 2004 | Short voice | |
| Target | 2004 | | Nolan |
| Without a Trace | 2004 | TV Series | Doctor |
| The Parkers | 2003 | TV Series | Zorah |
| The Proud Family | 2002-2003 | TV Series | Oprah Winfrey / Basil / Tobasco |
| Skin Deep | 2003 | | Alex |
| Clone High | 2002-2003 | TV Series | Girl in Commercial Harriet Tubman Eva Peron ... |
| Rapsittie Street Kids: Believe in Santa | 2002 | TV Movie | Great Grandma (voice) |
| Jane White Is Sick & Twisted | 2002 | | Chi-Chi |
| The Oblongs | 2001 | TV Series | |
| Gary & Mike | 2001 | TV Series | Additional voices |
| Accidents Don't Happen | 2001 | | Julia |
| The Mr. Potato Head Show | 1998-1999 | TV Series | Queenie / Queen Sweet Potato / Miss Licorice Lips |
| Star Trek: Deep Space Nine | 1998 | TV Series | Lisa Cusak |
| Star Trek the Experience: The Klingon Encounter | 1998 | Short | Security Officer |
| Sleeping Together | 1997 | | Wendy |
| Asylum | 1997/I | | Belinda Davis |
| Soulmates | 1997 | | Jennifer Williams |
| B*A*P*S | 1997 | | Flight Attendant |
| Gridlock'd | 1997 | | Medicaid Woman #2 |
| Girl 6 | 1996 | | Salesgirl #3 |
| New York Undercover | 1995 | TV Series | Shanna |
| Blue in the Face | 1995 | | Statistician |
| Cracking Up | 1994 | | |
| The Uptown Comedy Club | 1992 | TV Series | Various Characters |
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